Vertex Pharmaceuticals Incorporated : 2024 (2024 Political Engagement Principles)

VRTX

POLITICAL ENGAGEMENT PRINCIPLES

Our Mission

Every day, Vertexians work hard to improve the lives of patients. In so doing, we recognize the importance of public policy in supporting our mission of creating transformative medicines for people with serious diseases. Public sector decisions significantly affect our business and industry, as well as the communities in which we operate and the patients that we serve. It is therefore critical for us to interact with policymakers across the political spectrum to advocate for policies that benefit patients and foster biopharmaceutical innovation and advancement.

We have regular and constructive engagement with government officials and policymakers at the federal, state, and local levels to promote an innovative, patient-focused policy environment. We also contribute to state and local candidates and political organizations where permitted by applicable law. Our participation in the political process is guided by ourCode of Conduct.

Management and Board Oversight

The Vertex Board of Directors has oversight over the Company's public policy activities, including political contributions and lobbying, and reviews our public policy and lobbying priorities at least annually. Our Head of U.S. Public Affairs is responsible for approving all corporate political contributions and ensuring that they align with our mission and business priorities. Political contributions are made without regard for the private political preferences of Vertex executives.

Lobbying and Political Activities

Lobbying

We comply with the Lobbying Disclosure Act and file quarterly reports listing the issues for which we are conducting lobbying activities and the amounts we spend in support of those activities, including (i) total federal lobbying expenditures, (ii) the name of the specific piece of legislation or subject that was the topic of communication, (iii) disclosure of Vertex individuals lobbying on behalf of Vertex, and (iv) identification of the legislative body or executive branch that was contacted. Our latest federal lobbying disclosure filings are available on theU.S. SenateOffice of Public Records website and theU.S. House of Representatives Office of the Clerkwebsite.

Lobbying disclosure rules also often apply at the state and local levels. We have included, and will update annually, an Appendix listing the states in which we file lobbying reports and, to the extent available, links to state websites where such information can be found.

We do not engage in grassroots lobbying communications.

Political Contributions

Vertex contributes to state and local candidates where permitted by applicable law. Our contributions are bipartisan and support candidates and policies that will enable us to create transformative medicines for people with serious diseases, including those that further biopharmaceutical innovation and access to medicines; help patients with serious diseases; and impact our employees or geographic areas where our facilities are located. We also may provide financial support to other political organizations, including 527 organizations. A list of these contributions will be updated annually in the Appendix.

Vertex does not make independent political expenditures and does not make payments to influence ballot measures.

At times, Vertex may contribute to 501(c)4 organizations that engage in lobbying or political activity. We will disclose such organizations annually in the Appendix and, to the extent available to us, the portion of those payments used for activities that are not deductible under Chapter 162(e) of the Internal Revenue Code. Vertex does not contribute funds intended for elections to 501(c)4 organizations.

VPAC

The Vertex Political Action Committee (the "VPAC") is a nonpartisan organization that contributes to federal and state candidates across the political spectrum. VPAC-supported candidates share our commitment to ensuring access to transformative medicines and recognize the vital contributions that Vertex and its employees make in discovering medicines that can prevent, cure or fundamentally change the outcomes of serious diseases for patients and their families. VPAC takes into consideration many issues that are important to meeting the needs of the patients we serve, our employees, and our company. A contribution from VPAC does not mean that Vertex agrees with the candidate on every issue.

The VPAC is funded entirely by voluntary contributions from employees and members of our Board of Directors. Federal law prohibits corporations from making direct contributions to federal candidates, political parties, and political committees. Companies are permitted to administer a political action committee funded solely by voluntary employee contributions.

VPAC's contributions are publicly disclosed in reports with the U.S. Federal Elections Commission available here:www.fec.gov/data/committee/C00468660/. All VPAC spending decisions are reviewed by the VPAC Board of Directors and are approved by Vertex's Head of U.S. Public Affairs.

Trade Organization and Industry Group Memberships

Vertex is a member of industry and trade groups that are aligned with our business objectives and our political contributions philosophy. Our government affairs executives evaluate our participation in these organizations regularly to ensure alignment with our contribution criteria and principles.

While we may not always agree with the positions taken by these organizations or their members, we are committed to participating in the discussions. In some instances, these organizations may use membership dues to engage in lobbying activities. We do not direct, nor have discretion over, how these funds are used.

In 2024, the industry and trade organizations to which Vertex paid more than $25,000 in membership dues or other payments, and to the extent available to us, the portion of those payments that were used for activities that are not deductible under Chapter 162(e) of the Internal Revenue Code were:

Organization

Non‐Deductible Portion of Payments ($)

Biotechnology Innovation Organization

185,701

California Life Sciences Association

10,640

Texas Healthcare and Bioscience Institute

3,500

Massachusetts Biotechnology Council

4,000

New York Bio

432

Appendix

Lobbying Disclosures by Registered State Jurisdiction

Alabama

http://ethics.alabama.gov/lobbyists.aspx

Arizona

https://lobbying.az.gov/

Arkansas

https://www.sos.arkansas.gov/elections/financial-disclosure/registered-lobbyists-political-action-committees

California

http://cal-access.sos.ca.gov/Lobbying/

Colorado

https://www.sos.state.co.us/pubs/lobby/lobby_home.html

Connecticut

https://portal.ct.gov/Ethics/Lobbyist-Filings/Lobbyist-Filings/Lobbyist-Main-Page

Delaware

https://depic.delaware.gov/

District of Columbia

https://bega.dc.gov/page/resources-lobbyists

Florida

https://floridalobbyist.gov/

Georgia

https://ethics.ga.gov/lobbyist-reporting/

Idaho

https://sos.idaho.gov/elections-division/lobbyist-information/

Illinois

https://www.ilsos.gov/lobbyistsearch/

Indiana

https://www.in.gov/ilrc/

Iowa

https://www.legis.iowa.gov/lobbyist

Kansas

https://www.kssos.org/elections/elections_lobbyists.html

Kentucky

https://klec.ky.gov/Pages/default.aspx

Louisiana

http://ethics.la.gov/lobbyinghome.aspx

Maine

https://www.maine.gov/ethics/lobbyists

Maryland

https://lobby-ethics.maryland.gov/

Massachusetts

https://www.sec.state.ma.us/LobbyistPublicSearch/

Michigan

https://www.michigan.gov/sos/0,4670,7-127-1633_11945---,00.html

Minnesota

https://cfb.mn.gov/citizen-resources/board-programs/overview/lobbying/

Mississippi

https://lobbying.sos.ms.gov/elec/portal/msel/page/search/portal.aspx

Missouri

https://mec.mo.gov/MEC/Lobbying/Home.aspx

Montana

https://lobbyist-ext.mt.gov/LobbyistRegistration/

Nebraska

https://nadc.nebraska.gov/lobbying

Nevada

https://www.leg.state.nv.us/Lobbyist

New Hampshire

https://www.sos.nh.gov/lobbyists

New Jersey

https://www.elec.nj.gov/forcandidates/gaa_ed_train.htm

New Mexico

https://www.cfis.state.nm.us/media/ReportLobbyistFilingPeriods.aspx

New York

https://jcope.ny.gov/public-data

North Carolina

https://www.sosnc.gov/divisions/lobbying

North Dakota

https://sos.nd.gov/lobbyists

Ohio

http://www.jlec-olig.state.oh.us/?page_id=4

Oklahoma

https://www.ok.gov/ethics/State_Officers_&_Employees/Lobbying/

Oregon

https://www.oregon.gov/ogec/public-records/Pages/Lobby-Registrations-andExpenditure-Reports.aspx

Pennsylvania

https://www.dos.pa.gov/OtherServices/LobbyingDisclosure/Pages/default.aspx

Rhode Island

https://www.sos.ri.gov/divisions/open-government/transparency/lobbying

South Carolina

https://apps.sc.gov/lobbyingactivity/LAIndex.aspx

South Dakota

https://sosenterprise.sd.gov/businessservices/lobbyist/default.aspx

Tennessee

https://apps.tn.gov/ilobby/

Texas

https://www.ethics.state.tx.us/search/lobby/loblistsREG2016-2020.php

Utah

https://lobbyist.utah.gov/Search/PublicSearch

Vermont

https://lobbying.vermont.gov/

Virginia

http://ethics.dls.virginia.gov/lobbyists.asp#prepare

Washington

https://www.pdc.wa.gov/browse

West Virginia

https://ethics.wv.gov/lobbyist/Pages/Reporting.aspx

Wisconsin

https://lobbying.wi.gov/Home/Welcome?session=2019REG

Wyoming

https://lobbyist.wyo.gov/Lobbyist/Default.aspx

2024 Corporate Contributions to State and Local Political Candidates

Name

State

Amount

Committee to Elect Butch Parrish

GA

1000

Friends of Jessica Bateman

WA

1000

Friends of Jesse Pippy

MD

500

Friends for Alonzo Washington

MD

500

Citizens for Antonio Hayes

MD

500

Friends of Don Harmon

IL

1000

Matt Gambill Campaign For State House

GA

500

Citizens for Castro

IL

500

Syverson for Senate

IL

500

Josh Harkins Senate Campaign Fund

MS

500

Bo Watson for Senate

TN

1000

Friends of Terri Bryant

IL

500

Lee Hawkins Campaign Fund

GA

500

Derrick Simmons for State Senate Campaign Fund

MS

500

Hoover for Assembly 2024

CA

2000

Republican Assembly Campaign Cmte-SEG FUND

WI

1250

Dr. Bill Wheat Campaign

LA

500

Friends of Candi Mundon King

VA

1000

Robert Rivas for Assembly 2024

CA

2000

Louis Ruiz for Kansas

KS

250

Friends for Kathy Hochul

NY

4000

NH House Democratic Victory Campaign Committee

NH

500

AshPAC

MO

1000

Ryan McDougle for Senate

VA

1000

Friends of Chris Gorsek

OR

500

Friends of Steve Hershey

MD

1000

Alabama House Republican Caucus

AL

2000

Cameron Henry Campaign Fund

LA

1500

Ty Masterson for Kansas

KS

500

Friends of Jeff Helfrich

OR

1000

Sam Creekmore Campaign

MS

1000

Cyrus for Oregon

OR

500

Kansas for Blex

KS

250

Tasha Boerner Horvath for Assembly 2024

CA

1000

Murrell Smith Campaign

SC

500

Billy Mitchell Campaign Fund

GA

500

Green for Louisiana

LA

500

The Committee to Elect Gary Carter, Jr.

LA

500

Brock Martin for State Representative

TN

1000

Friends of Win Stoller

IL

500

Campos for Oregon

OR

500

Thomas Pressly for State Senate

LA

500

Ed Diehl for Oregon

OR

500

Friends of Justin Ready

MD

600

Terry L. Austin for House of Delegates

VA

1000

Blakespear for Senate 2026

CA

1500

Bob Owen Campaign

LA

1000

Chase Blasi for State Senate

KS

500

Citizens for Elizabeth Hernandez

IL

500

Heath Flora for State Assembly 2024

CA

1000

Committee for Elect Clark Boyd

TN

1000

Woodard for Kansas

KS

250

Committee to Elect Royce Duplessis

LA

500

Friends Of Jehan Gordon-Booth

IL

500

Sickles For Delegate

VA

1000

NEMO Leadership Pac

MO

1000

Kevin Blackwell Campaign Fund

MS

500

Friends of Rob Nosse

OR

500

Alabama Senate Republican Conference

AL

2000

Friends of Robyn Gabel

IL

500

Shane Reeves for State Senate

TN

1000

Committee to Elect William Lamberth

TN

1000

Committee to Elect Alonzo Knox

LA

500

Jason White Campaign Fund

MS

1000

Faust-Goudeau for Kansas

KS

250

Friends of Caleb Hemmer

TN

1000

Cullison for Maryland

MD

500

Friends of Lillian Ortiz-Self

WA

500

Barbara West Carpenter Committee

LA

500

Friends of Clarence Lam

MD

500

Snaza for State

WA

1000

Wayne McMahen Campaign

LA

500

Friends of Mattie Hunter

IL

500

Laurie Davies for Assembly 2024

CA

1000

Citizens for Lightford

IL

500

Committee to Elect Tony McCombie

IL

1000

Buehler 4 Kansas

KS

250

State Senate Democratic Committee-Seg Fund

WI

750

Missouri Alliance PAC

MO

1500

Committee to Elect Edith Patterson

MD

300

Dr. Jasmeet Baines for Assembly 2024

CA

1000

Citizens for Bill Ferguson

MD

1500

Northland Forward

MO

1000

Committee to Elect House Republicans

NH

500

Willett for Delegate

VA

1000

Joseph Bouie, Jr. Campaign

LA

500

Megan Dahle for Senate 2024

CA

1000

NYS Republican Assembly Campaign Committee Housekeeping Account

NY

3750

H-PAC

MO

1000

Friends of Kathy Klausmeier

MD

250

Friends of Melissa Wells

MD

250

Friends of Robert "Bob" Rita

IL

500

Citizens for Jackie Haas

IL

500

Blake Carpenter for State Representative

KS

250

Steven Jackson Campaign

LA

500

Honest Leadership

FL

5000

Citizens for Laura Murphy

IL

500

Friends of Julie Fahey

OR

1000

Senator John Braun

WA

1000

Friends of Ghazala Hashmi

VA

1000

Maine Democratic State Committee

ME

20000

Friends of Rob Wagner

OR

500

Committee to Elect Vanessa Atterbeary

MD

500

Katie Dempsey Campaign Fund

GA

1000

Lori Wilson for Assembly 2024

CA

1500

Friends of Laurie Jinkins

WA

500

Assembly Democratic Camp Comm-SEG FUN

WI

750

Stephanie Berault Campaign

LA

500

Jimmy Harris Campaign Fund

LA

500

Jason Hughes Campaign Fund

LA

500

Friends of Joseline Pena-Melnyk

MD

1000

Elect Monical Stonier

WA

500

DougPAC

MO

1000

Plummer for Illinois

IL

500

Friends of Marcus Riccelli

WA

500

Oropeza for Kansas

KS

250

Brach Myers Campaign

LA

500

New Hampshire Senate Democratic Caucus

NH

500

Friends of Johnny Mautz

MD

550

Sam L. Jenkins, Jr. Campaign Committee

LA

500

Ed Price for Senate

LA

500

Tonya Anderson for State Senate District 43

GA

500

Buckel for Delegate

MD

1000

Brad Stephens for State Representative

IL

500

Friends of LaPointe

IL

500

Friends of Jheanelle Wilkins

MD

1000

Friends of Michelle Maldonado

VA

1000

Sabi Kumar for TN House

TN

1000

NY Republican Senate Campaign Committee Housekeeping Account

NY

3750

Missouri Leadership PAC

MO

1500

Hawk for State Representative

TN

1000

Cameron Sexton for State Representative

TN

1750

Lindsay Vaughn for Kansas House

KS

250

Carl Turner for Kansas

KS

250

Friends of Lisa Reynolds

OR

500

Gerald Boudreaux Campaign

LA

500

Hayes for Delegate

VA

1000

Friends of Jeff Keicher

IL

500

Friends of Dr. Todd Pillion

VA

1000

Friends of My-Linh

WA

500

Glen D. Womack Campaign

LA

500

Chris Croft for Kansas

KS

500

Friends of Sue Rezin

IL

500

Bob Hensgens Campaign Fund

LA

500

Amy Walen for State House

WA

500

Larry Selders

LA

500

Ashby for Senate 2026

CA

1000

Heart of SGF PAC

MO

1000

Friends of Hai Pham

OR

500

Friends of Pam Beidle

MD

1000

Friends of Cory McCray

MD

250

B PAC

MO

1000

Angela Cockerham Campaign Fund

MS

500

Rhonda Butler Campaign

LA

500

Joe Stagni for State Representative

LA

500

Citizens for Adrienne Jones

MD

500

W. Briggs Hopson Campaign Fund

MS

500

Citizens for Hauter

IL

500

Patrick Moore McMath Committee

LA

1000

Pat Pettey For Kansas Senate

KS

500

New Hampshire Senate Republicans PAC

NH

500

Committee to Elect Bo Mitchell

TN

1000

Friends of Janet Yang Rohr

IL

250

Friends of J.B. Jennings

MD

1000

Katrina Jackson Campaign

LA

500

Friends of Todd Nash

OR

500

Kirk Talbot Campaign

LA

500

Jason Brodeur Campaign Fund

FL

1000

Mary Margaret Oliver Campaign Fund

GA

500

John Ray Clemmons for TN House

TN

1000

Greg Wallis for Assembly 2024

CA

1500

Friends to Elect Elaine Davis

TN

1500

Menjivar for Senate 2026

CA

1000

Friends to Elect Raumesh Akbari Senate

TN

1000

Friends of Kathy Szeliga

MD

550

Hob Bryan Campaign Fund

MS

1000

Friends of Ron Muzzell

WA

1200

The Committee to Elect Esther Helton

TN

1000

Dietrich for Senate

KS

500

Pittman for Senate

KS

500

Friends of Marcia Price

VA

1000

Michelle Au Campaign Fund

GA

500

Citizens for Teresa Reilly

MD

550

Citizens for Karina Villa

IL

500

Committee to Elect Holscher

KS

500

The Adrian Fisher Campaign

LA

500

Citizens for Sara Feigenholtz

IL

500

Dr. Akilah Weber for State Senate 2024

CA

1500

Renee Erickson for Kansas Senate

KS

500

Kay Kirkpatrick Campaign Fund

GA

500

Friends of Guy Guzzone

MD

500

Dustin Miller Campaign Fund

LA

750

Vadenia Winn For Kansas House

KS

250

Eastside Forward PAC

MO

1000

Trey Lamar Campaign for State House

MS

500

Citizens for Thomas Hutchinson

MD

500

Friends of John Curran

IL

1000

Rosilicie Ochoa Bogh for Senate 2024

CA

500

Sykes for Senate

KS

500

Committee to Elect Phillip Devillier

LA

1500

Friends of Paul Corderman

MD

550

Friends of Mike Cherry

VA

1000

Citizens for Matt Morgan

MD

550

Julie Morrison for State Senate

IL

500

Mike McLane for Oregon

OR

500

Friends of Ken Kerr

MD

500

Alabama Democratic Senators

AL

1000

Citizens for Brian Chisholm

MD

550

Friends of Harold Love

TN

1000

Sheree Sample-Hughes Campaign Fund

MD

300

Friends to Elect Andre V. Johnson

MD

200

Friends of Ryan Spain

IL

500

Friends of Terri Hill

MD

300

Stacey Hobgood-Wilkes Campaign Fund

MS

1000

Gallagher for Assembly 2024

CA

3000

Friends of Fred Girod

OR

500

People for Emanuel Chris Welch

IL

1000

Disclaimer

Vertex Pharmaceuticals Incorporated published this content on March 31, 2025, and is solely responsible for the information contained herein. Distributed via , unedited and unaltered, on March 31, 2025 at 14:22 UTC.