Lineage Cell's Dry AMD Gene Therapy Demonstrate Functional, Anatomical Improvements

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  • Lineage Cell Therapeutics Inc LCTX reported updated interim results from its Phase 1/2a study of its lead product candidate, OpRegen cell therapy for dry age-related macular degeneration (AMD) with geographic atrophy (GA). 
  • Overall, 10/12 (83%) of the Cohort 4 patients' treated eyes continued to be at or above baseline visual acuity at their last assessment, ranging from six months to approximately three years post-transplant. 
  • Improvements in best-corrected visual acuity for Cohort 4 patients reached up to +19 letters. 
  • In contrast, 10/12 (83%) of the patients' untreated eyes were below pre-treatment baseline values at the same time points. 
  • Three patients with evidence of retinal tissue restoration continue to demonstrate areas of repair and sustained visual acuity improvements as of their last clinical visit.
  • One patient with confirmed atrophy growth at baseline has had zero progression for almost three full years.
  • The Company intends to meet with the FDA in Q4 of 2021 to discuss the clinical development plan for OpRegen.
  • Evidence of durable engraftment of OpRegen RPE cells has extended to more than five years in the earliest treated patients, supporting the potential for OpRegen to be a one-time treatment.
  •  Price Action: LCTX shares are up 3.88% at $2.68 during the market session on the last check Tuesday.
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Posted In: BiotechNewsPenny StocksHealth CareSmall CapGeneralBriefsgene therapyPhase 1 Trial
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