Masimo Announces the Findings of A Randomized Clinical Trial Published in Jama Pediatrics

Published: 2025-06-10 13:06:37 ET MASI

Published on 06/10/2025 at 13:06

Masimo announced the findings of a randomized clinical trial published in JAMA Pediatrics in which Dr. Yasuko Nagasaka and colleagues at Tokyo Women's Medical University demonstrated the ability of electroencephalogram (EEG)-guided anesthesia, using Masimo SedLine®? Brain Function Monitoring, to improve anesthesia administration in children undergoing surgery. The researchers found that the use of SedLine led to a significant reduction in the amount of a commonly used inhalation anesthetic (sevoflurane) needed to maintain anesthesia in pediatric patients, reducing their exposure to the drug.

In turn, the patients experienced a significantly lower rate of pediatric anesthesia emergence delirium, or PAED, which commonly manifests in confusion, agitation, or hallucinations experienced during recovery. When compared with standard practice, children monitored with SedLine also regained consciousness faster and could be safely discharged to the post-anesthesia care unit, or PACU, sooner - time savings that, the researchers noted, may represent additional cost savings. In sum, the researchers found that Masimo SedLine helped to make pediatric anesthesia safer, more efficient, and more cost effective.

The findings suggest that high concentrations of sevoflurane for induction followed by routine use of 1.0-MAC sevoflurne for maintenance may be excessive. They also noted that "with EEG monitoring, parents and guardians may be reassured that health care professionals can make an active effort to reduce and minimize a child's exposure to anesthetic drugs." A similar study in 2022 by Long et al. - one of the first to investigate the impact of EEG-guided anesthesia on children undergoing surgery - found that pediatric patients monitored with SedLine experienced significantly fewer EEG patterns of profound brain inactivity, known as burst suppression.

Burst Suppression has also been associated with adverse outcomes, including postoperative delirium.