ASP Isotopes : Company Presentation (ASPI corporate overview 2026 04 13)
ASPI
Published on 04/13/2026 at 09:20 am EDT
1 | © ASP Isotopes Inc.
April 2026
Scaling capacity, expanding portfolio, and improving unit economics
What We Do
Differentiated Isotope Enrichment Platform
▸ Aerodynamic Separation Process (ASP)
▸ Quantum Enrichment (QE)
High-Value End Markets
Electronics | Nuclear Medicine | Nuclear Energy1
Growing Diversified Operating Footprint
U.S. | Europe | South Africa
Three Isotope Enrichment Facilities Built in South Africa
Yb-176 | Si-28 | C-14
Value Drivers
▸ Scale Capacity across enrichment programs to meet growing demand
▸ Broaden the Portfolio to capture more of the value chain
▸ Improve Unit Economics through proprietary process optimization
▸ Strategic Partnerships to accelerate commercialization
Proof & Milestones
Advancing Lead Assets
Technical progress across Yb-176, Si-28, and C-12 enrichment programs
Building Commercial Traction
Customer engagement and supply agreements in high-value end markets
First Commercial Shipments2
Si-28 · C-14 · Yb-176
The Energy Act of 20203 defines a "critical material" as:
Any non-fuel mineral, element, substance or material that the Secretary of Energy determines: (i) has a high risk of supply chain disruption; and (ii) serves an essential function in one or more energy technologies, including technologies that produce, transmit, store, and conserve energy.
1. Our enrichment technologies cannot be tested on uranium unless and until required regulatory approvals and permissions have been obtained.
| © ASP Isotopes Inc. 2. Delivery dates reflect management targets and are subject to operational readiness. C-14: Carbon-14; Si-28: Silicon-28; Yb-176: Ytterbium-176.
3. Section 7002(a), Energy Act of 2020 (P.L. 116-260).
ASP Isotopes Inc.
Delaware, US
NASDAQ (ASPI)
Radiopharmacy Platform
Scalable PET isotope manufacturing for the nuclear medicine market
Three Radiopharmacies supplying thousands of doses of radiomedicines every year.
Emerging Pipeline of Theranostics to treat oncology.
Alpa Theranostics
IsoBio
Opeongo
Stable Isotopes Production Platform
Three stable isotope production facilities in South Africa
Silicon - 28 for next generation semiconductors
Carbon - 14 for nuclear medicine
Ytterbium - 176 for nuclear medicine
Plans to construct additional facilities in Iceland, UK and U.S.A.
Helium & LNG Production
Virginia Gas Project
Helium - Noble gas used in production of semiconductors, healthcare and rocketry.
LNG - Liquified natural gas for energy.
Capturing a Fragile Nuclear Fuel Supply Chain
QLE plans to supply:
Much needed conversion services.
Enriched U-235 via QE and ASP technology1
Deconversion of enriched uranium for fuel fabrication.
Lithium - 7 which is critical to pH control in PWRs and molten salt reactors
Lithium - 6 for use in future nuclear fusion
Nuclear Fuels
Nuclear Medicine Electronic Gases (inc. Helium) LNG
1 Our enrichment technologies cannot be tested on uranium unless and until required regulatory approvals and permissions have been obtained.
| © ASP Isotopes Inc.
Isotopes have one of the most severely compromised supply chains of any material in the world. The US Department of Energy and the majority of Western governments identify isotopes as critical materials.1
Electronics
Supplying materials for next-generation computing
Quantum computing, quantum sensing, and AI are expected to drive demand for isotopically enriched materials, helium, and fluorinated gases.
ASP Isotopes has signed Silicon-28 supply agreements with leading industry participants.1
Helium and other electronic gases for semiconductor manufacturing
Nuclear Medicine
Supporting growing demand for medical isotopes
Medical isotope demand is increasing as radiopharmaceuticals gain broader adoption in oncology.2
ASP Isotopes is building enrichment capacity to support Lu-177 and other high-value isotope applications.2
Nuclear Energy
Positioned for advanced nuclear fuel demand
Through QLE, the company is pursuing initiatives tied to next-generation nuclear fuel production.3
These efforts are intended to support the future fuel needs of SMRs and advanced reactors.3
1 U.S. DOE Isotope Program identifies isotopes as critical to national security, medicine, and advanced manufacturing (DOE Office of Science). 2 Radiopharmaceuticals market projected at ~10.8% CAGR to
| © ASP Isotopes Inc. $19.7Bn by 2033 (DataM Intelligence); Lu-177 market $2.1Bn (2024), projected $7.4Bn by 2034 (InsightAce Analytic). 3 NEI estimates ~3,000 MT HALEU demand by 2035; no Western producer at commercial scale (ASPI/QLE Press Releases; Nuclear Energy Institute. Our enrichment technologies cannot be tested on uranium unless and until required regulatory approvals and permissions have been obtained.
Expected Q2 2026 Milestones
Si-28 Electronic
First enriched Si-28 product expected to ship in Q2
Expected 2H 2026 Milestones
C-14 Nuclear Medicine
Targeting initial C-14 commercial shipments around mid-year, depending on arrival of feedstock from Canadian customer1
Yb-176 Nuclear Medicine
Targeting initial commercial shipments for YB-176 around mid-year/Q3
Helium Electronic
Expect to obtain Helium Phase 1 nameplate capacity in Q3
Radiopharmaceuticals Nuclear Medicine Continue growth of radiopharmacy operations
Advance multiple pipeline assets towards Phase 1 human clinical trials1
EBITDA TARGET: >$300 Million in 20312
| © ASP Isotopes Inc.
1 Operational milestones represent current expectations of management based on information available as of the date hereof. 2 EBITDA target is a management estimate based on current business plans and assumptions; not a guarantee of future performance.
What is Isotope Enrichment?
Isotope enrichment is the process of increasing the concentration of a desired isotope. For example, enriched Silicon-28 has a concentration of
99.995%+ vs its 92.2% natural concentration, removing Silicon-29 and 30 isotopes
What is an Isotope?
ATOMIC STRUCTURE
Atoms of the same element with the same number of protons but different numbers of neutrons
Similar chemical behavior but can have different physical properties, including mass
Can be stable or radioactive, depending on the structure of the nucleus
Atoms
Enriched isotopes have one of the most severely compromised supply chains of any material in the world with most of the world reliant on Russia for supply.
Isotope Market Producers1
85%
85%
15%
Russia (85%)
Rest of the world (15%)
ASP Isotopes is working to address this problem.
15%
Russia (85%) Rest of the world (15%)
Differentiated technology platform built to serve large, supply-constrained, high-value isotope markets.
AERODYNAMIC SEPARATION PROCESS (ASP)
QUANTUM ENRICHMENT (QE)
Utilizes gaseous diffusion via a stationary wall centrifuge paired with proprietary flow directors to separate isotopes of varying atomic mass. Best suited for lighter gases.
Employs precisely tuned lasers and quantum mechanical principles to separate isotopes based on unique transition energies. Ideal for heavier metals.
KEY ADVANT AGES KEY ADVANT AGES
Best-in-class for lighter gases (Si-28, C-12, C-14)
Scalable volume production
Superior cost vs. competitors globally
Most metals enrichable (Yb-176, Li-6/7, etc.)
Extremely capital light
High selectivity for precise isotope targeting
ASP SEPARATION PROCESS QE LASER ENRICHMENT PROCESS
Our enrichment technologies cannot be tested on uranium unless and until required regulatory approvals and permissions have been obtained.
Carbon-12/ 14 (C-12/ C-14) Silicon-28 (Si-28) Ytterbium-176 (Yb-176)
Enriched Carbon-12 for advanced semiconductor and quantum computing substrates. Critical feedstock for next-gen chip manufacturing.
Enriched Silicon-28 for Gate All Around transistors and advanced thermal management in next-generation semiconductors.
Enriched Ytterbium-176 for nuclear medicine theranostics. Precursor to Lutetium-177, a key cancer treatment isotope.
Semiconductors and Quantum Sensing
Electronic Gases
Estimated global market for
electronic gases (estimated 7.5% CAGR)1
ASP Isotopes is building a strategic position across high-value segments of the specialized electronic gases supply chain2
Silicon-28 for next generation Gate
All Around Transistors3
Fluorinated Gases and Helium Unique Isotopes
01 02 03 04 05 06 07 08 09
Silane
Epitaxy
300mm
EUV Laser
Semiconductor
Dicing
Chip
Sealed
Ready for
Gas
Boules
Wafers
Etching
Layers
Chips
Packaging
Chips
Gadgets
1. Electronic specialty gases market projected to reach ~$11.3B by 2030 at 6.8% CAGR. Source: Strategic Market Research (2024). 7.5% CAGR reflects company estimates for sub-segments relevant to
13 | © ASP Isotopes Inc. ASP Isotopes. 2. This slide contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. ASP Isotopes' strategic positioning is subject to market, regulatory, and operational risks 3. Si-28 for Gate-All-Around (GAA) transistors reflects management's view of anticipated semiconductor industry demand; commercial adoption timelines are uncertain.
Estimated global market for silane in semiconductor applications
Standard silicon environment:
Heat generation due to Silicon-29 and Silicon-30 scattering Phonons
Enriched Silicon-28 environment
Reduced scattering supports improved thermal flow
Simple visual representation of Phonon scattering causing thermal increases due to Si-29 and Si-30. Followed by a representation of phonon flow in enriched Silicon-28.
The #1 bottleneck in next-gen chip performance is heat dissipation and thermal conductivity. As chips shrink and power density rises, thermal management becomes the critical limiting factor - exactly where Silicon-28 delivers.
Our enriched Silicon-28 is expected to be fab-ready (99.99999% chemical purity); at 99.9% isotopic purity, it delivers 160%-300% thermal conductivity gains in next-gen GAA transistors.
Removing Si-29 and Si-30 reduces phonon scattering, dramatically improving heat flow.
All leading fabricators are racing to produce high-functional GAA chips. The leading costs driven by thermal issues are both energy consumption and shorter depreciation schedules - we believe our solution can address both in a significant way.
We plan to capture the next generation of chips through our zero spin isotopes for quantum uses.
Classical computers process information using bits that exist in one of two states (0 or 1). In contrast, quantum computers employ qubits, which can exist in a superposition of states (and entanglement), enabling them to represent and process multiple possibilities simultaneously.
Enrichment of Silicon-28 and Germanium-70 to 99.995% isotopic purity with the chemical requirements for fabricators is expected to allow large fabs to utilize their current silicon and germanium infrastructure for quantum chips.
Enrichment of Carbon-12 to 99.995% isotopic purity is expected to allow for the production of diamond films and NV Diamond materials due to the zero spin characteristics of Carbon-12.
Other Materials, such as Ytterbium-171, Nitrogen-15 and others, are isotopes with lower or zero spin that we may produce for the industry.
It is critical that the materials deployed for these computers have zero-spin which reduces magnetic noise, increases coherence, and increases inference.
W hy helium is essent ial for advanced chip f abricat ion
Helium Applications by Industry (%)
AI Chip Market Doubling by 2030
AI-driven chip market forecast to grow at a CAGR of ~16%1
Superior Thermal Conductivity
Ideal for precisely controlling wafer temperatures
Chemical Inertness
Prevents unwanted chemical reactions during fabrication
Semiconductor Mfg Defense Signals & Guidance
Helium Hard Drives
Cooling Fiber Optic
20%
18%
17%
15%
30%
Used at Every Stage of Chipmaking
GPU cooling and advanced semiconductor fabrication
No Substitute & Rising Intensity
Helium use per wafer expected to increase with chip complexity
Argon
Air Nitrogen Helium
Thermal Conductivity (W/mK)
0.018
0.026
0.026
0.152
3Q 2026
Nameplate Capacity for Helium
$750M
Conditional Commitments for Debt Funding5
~60%
Phase 1 LNG Contracted
12x
Phase 2 vs Phase 1 Scale
PRODUCTION OVERVIEW
Phase 1 Production
▸LNG: ~2,500 GJ/day | Revenue >$12M/yr1
▸Liquid Helium: ~58 MCF/day | Revenue >$8M-$19M/yr2 2026 Milestones
▸Q1: Completed drilling of wells required for Phase 1 project
4 months ahead of schedule
▸Q3: Expect to obtain nameplate capacity for Helium
Phase 2 Expansion
▸LNG: ~34,000 GJ/day | Revenue >$170M/yr1
▸Liquid Helium: ~900 MCF/day | Revenue >$120M/yr2
▸~7% of global helium production3
PRICING & FUNDING
Helium Pricing
▸Spot: variable2
▸Contract: ~$280-$400/Mcf4
▸Conc. 10x+ global avg3
LNG Pricing
▸Diesel-indexed: ~$12-$20/ GJ1
Senior Debt Funding
▸$500M U.S. DFC senior facility for Phase 25
▸$250M Standard Bank SA for Phase 25
▸$40M existing DFC loan (Phase 1)5
1: Assuming LNG selling price ~$14/GJ; 2: Variable helium pricing from $380-$1,200/MCF; 3: Based on est. global helium supply of ~6 BCF/yr; 4: Based on current market contract
ASP Isotopes' scientists have developed proprietary methods for manufacturing fluorinated compounds and have constructed a pilot plant in Pretoria with nameplate capacity of up to 220 tons per annum of fluorinated rare earth metals.
Specialized gases used across key semiconductor manufacturing steps
Fluorine (F2) and Fluorine mixtures (F2/N2), Phosphorus trifluoride (PF3), Iodine pentafluoride (IF5), and Selenium tetrafluoride (SeF4) are used in plasma etching processes to selectively remove material and create precise patterns on semiconductor wafers.
Dopants such as Germanium tetrafluoride (GeF4) and Antimony pentafluoride (SbF5) are introduced to modify electrical properties.
Germanium tetrafluoride (GeF4), Molybdenum hexafluoride (MoF6), Niobium pentafluoride (NbF5), and Selenium tetrafluoride (SeF4) are used in chemical vapor deposition processes to deposit thin films of materials like silicon dioxide.
ISOTOPE
APPLICATION
R&D
EVALUATION
CONSTRUCTION
EXPECTED
MARKET ENTRY
TECHNOLOGY
Carbon-12
QC, Semi's
✓
✓
✓
2026
ASP
Silicon-28
QC, Semi's
✓
✓
✓
2026
ASP
Germanium-70
QC
✓
✓
✓
2026
ASP
Yb-171
QC
✓
-
-
2027+
QE
Nitrogen-15
QC
✓
-
-
2028
-
C-14
BetaVoltaics
✓
✓
✓
2028
(Demand driven date)
ASP
He-3
QC, Semi's
✓
-
-
N/A
Not Disclosed
✓ = Complete - = Pending ASP = Aerodynamic Separation QE = Quantum Enrichment
Theranostics, PET, and SPECT
Disclaimer
ASP Isotopes Inc. published this content on April 13, 2026, and is solely responsible for the information contained herein. Distributed via Public Technologies (PUBT), unedited and unaltered, on April 13, 2026 at 13:19 UTC.