Codexis, Inc. Presents Data at the Tides USA Annual Meeting in San Diego, California

Published: 2025-05-22 07:50:21 ET CDXS

Published on 05/22/2025 at 07:50

Codexis, Inc. presented data at the TIDES USA annual meeting in San Diego, California. Codexis' presentations showcased its proprietary ECO Synthesis platform's ability to support siRNA manufacturing by reducing purification costs, improving process performance, and demonstrating the potential to control stereochemistry. During an oral Main Stage presentation, Codexis used inclisiran as an example to showcase how the use of mobilized enzymes in its ECO Synthesis platform delivers a consistent process with improved performance.

Using sequential enzymatic synthesis, company: Continued to achieve consistent coupling efficiency of >98% Maintained the delivery of high product quality; Successfully decreased average cycle time by approximately 24%, translating into reduced production time; Demonstrated high yields of 30 grams of siRNA per liter. Using Codexis' ligase to manufacture siRNA, company data demonstrated the potential to reduce or eliminate costly downstream purification steps. This benefit of ligation has led many companies to explore using this method in siRNA manufacturing.

The company's poster presentation highlighted how the Company's recently launched machine learning tool is improving the success rate of ligation to produce siRNA. The tool aids process design by guiding the selection of optimal pairings of ligases and RNA fragments and has been shown to significantly outperform traditional fragment selection by four to sixfold. By accelerating the ligase selection process and maximizing ligation efficiency, this tool demonstrates the potential to reduce process development time, lower costs, and enable an efficient manufacturing process for customers.

Three CDMO Collaborator Presentations feature the Use of Codexis Ligases to Combine Short RNA Fragments: In addition to Codexis' presentations, Bachem, Nitto Avecia, and ST Pharm, three leading CDMOs in siRNA manufacturing, presented data on the use of Codexis ligases to successfully combine short RNA fragments. In a separate TIDES Talk presentation, Codexis highlighted a new feature under development for the ECO Synthesis technology to allow for stereochemical control during oligonucleotide synthesis. In contrast, the data in this oral presentation demonstrate how the ECO Synthesis platform can enable control over stereochemistry under process-relevant conditions.