Fennec Pharmaceuticals : Corporate Presentation January 2022

FENC

January 2022 | Corporate Presentation

www.fennecpharma.com

Safe Harbor Statement

During the course of this presentation, we will make statements that constitute forward-looking statements. These statements may include operating expense projections, the initiation, timing and results of pending or future clinical trials, the actions or potential action of the U.S. Food and Drug Administration (FDA), the status and timing of ongoing research, corporate partnering activities and other factors affecting the financial condition or operations of Fennec Pharmaceuticals, Inc. (Fennec).

Such forward-looking statements are not guarantees of future performance and involve risk, uncertainties and other factors that may cause actual results, performance or achievements to vary materially from those expressed or implied in such statements, including the risk that unforeseen factors may result in delays in or failure to obtain FDA approval of PEDMARKTM, the risks and uncertainties relating to the Company's reliance on third party manufacturing, the risks that the Company's NDA resubmission does not adequately address the concerns identified in the CRL previously provided by the FDA, the risk that the NDA resubmission to the FDA will not be satisfactory, that regulatory and guideline developments may change, scientific data and/or manufacturing capabilities may not be sufficient to meet regulatory standards or receipt of required regulatory clearances or approvals, clinical results may not be replicated in actual patient settings, unforeseen global instability, including political instability, or instability from an outbreak of pandemic or contagious disease, such as the novel coronavirus (COVID- 19), or surrounding the duration and severity of an outbreak, protection offered by the Company's patents and patent applications may be challenged, invalidated or circumvented by its competitors, the available market for the Company's products will not be as large as expected, the Company's products will not be able to penetrate one or more targeted markets, revenues will not be sufficient to fund further development and clinical studies

These and other risk factors are listed from time to time in reports filed with the SEDAR and the Securities and Exchange Commission, including but not limited to, reports on Forms 10-Q and 10-K. Fennec does not intend to update any forward- looking information to reflect actual results or changes in the factors affecting forward-looking information.

Corporate Deck 2

Fennec Pharmaceuticals, Inc. | A Snapshot

Focused on the development of PEDMARK™ for the prevention of cisplatin-induced ototoxicity in children (1 month to ≤ 18 years) with localized, non-metastatic solid tumors*

TWO successfully completed and published, randomized controlled studies in pediatric

patients

FAST TRACK and BREAKTHROUGH Therapy Designations granted by FDA

MAA to EMA submission completed in

February 2020

Potential for 7.5 YEARS U.S. market exclusivity

with Pediatric Orphan Drug Designation

Potential for 10 YEARS E.U. market exclusivity with Pediatric-useMarketing Authorization (PUMA), if granted

Patent Protection in U.S. until 2038 method of use for children <5 years of age

Patent Protection in U.S. until 2039

FDA issued CRL Nov 2021for the unique anhydrous form of the active ingredient, as well as related methods of synthesis

*PEDMARK is an investigational drug and has not yet been approved by the U.S. Food and Drug Administration (FDA) or any regulatory authority

NDA - New Drug Application

MAA - Marketing Authorization Application

PDUFA - Prescription Drug User Fee Act

Corporate Deck 3

FENNEC | Management Team

A dedicated management team with more than a decade of commitment to the development of PEDMARK and nearly two decades of demonstrated experience and commercialization success within the oncology space

Rosty Raykov

CEO & Director

Robert Andrade

Chief Financial Officer

Shubh Goel

Chief Commercial Officer

Mark Gowland

Controller

Corporate Deck 4

FENNEC | Board of Directors

Dr. Khalid Islam | Chairman

Dr. Islam has over 30 years of experience in drug discovery and development of anti- infectives, hematology/oncology and CNS therapies. Dr. Islam currently serves as the Managing Director of Life Sciences Management GmbH, since 2014. Previously, Dr. Islam served as Chairman and CEO of Gentium S.p.A., a Nasdaq-listed pharmaceutical company, from 2009 until 2014 (sold to Jazz Pharmaceuticals plc for $1 billion). He has also served as President and CEO of Arpida AG and held various positions at Sanofi-Aventis. Dr. Islam also currently serves as the Chairman of the Board of Directors for Minoryx Therapeutics and Gain Therapeutics and as a Member of the Board of Directors for Immunomedics, Inc. (IMMU).

Dr. Marco Brughera | Director

Dr. Brughera is Group Chief Executive Officer at Leadiant Biosciences S.p.A. Dr. Brughera has extensive experience in drug development, portfolio optimization, business development and general management, particularly in the oncology and rare disease areas. Dr. Brughera successfully out- licensed Defibrotide to Jazz Pharma and Oncaspar to Baxalta, Incorporated for over $1 billion. He is also an active board member for some life-science companies.

Jodi A. Cook, PhD | Director

Dr. Cook is the former head of gene therapy strategy at PTC Therapeutics, Inc. Previously, she was a founding member and Chief Operating Officer of Agilis Biotherapeutics, Inc., a gene therapy company focused on rare disease from 2013 until its acquisition by PTC Therapeutics, Inc. in 2018. She as held executive positions in a number of successful hearing industry biotech companies including Vice President of clinical research and professional relations at InSound Medical, Inc.

Adrian Haigh | Director

Mr. Haigh currently holds the position of SVP and General Manager Europe, ME and AP for PTC Therapeutics, Inc. and has had previous positions as Senior Vice President, Commercial Operations and Chief Operating Officer of Gentium GmbH, playing a pivotal role in the sale of Gentium to Jazz Pharma for $1 billion. Prior to joining Gentium, Mr. Haigh served as Regional Vice President, Commercial Operations at Biogen Idec.

Chris Rallis | Director

Mr. Rallis has served as a director of Fennec since August 2011. Mr. Rallis has been an executive-in-residence at Pappas Capital, a life science venture capital firm, since January 2008. Previously, Mr. Rallis was the President and Chief Executive Officer of ImmunoBiosciences, Inc. ("IBI"), a vaccine technology company formerly located in Raleigh, North Carolina, from April 2006 through June 2007. Prior to joining IBI, Mr. Rallis served as an executive in residence (part-time) for Pappas Ventures, and as a consultant for Duke University and Panacos Pharmaceuticals, Inc. Mr. Rallis is the former President and Chief Operating Officer ("COO") and director of Triangle Pharmaceuticals, Inc., which was acquired by Gilead Sciences, Inc. in January 2003 for approximately $465 million. Prior to assuming the role of President and COO in March 2000, he was Executive Vice President, Business Development and General Counsel. While at Triangle, Mr. Rallis participated in 11 equity financings generating gross proceeds of approximately $500 million. He was also primarily responsible for all business development activities which included a worldwide alliance with Abbott Laboratories and the in-licensing of ten compounds. Before joining Triangle in 1995, Mr. Rallis served in various business development and legal management roles with Burroughs Wellcome Co. over a 13-year period, including Vice President of Strategic Planning and Business Development. Mr. Rallis also serves on the board of Tenax Therapeutics, Inc., a biopharmaceutical company located in Morrisville, North Carolina. Mr. Rallis received his A.B. degree in economics from Harvard College and a J.D. from Duke University.

Corporate Deck 5

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Fennec Pharmaceuticals Inc. published this content on 17 January 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 17 January 2022 17:14:09 UTC.