Repare Therapeutics Provides Business and Clinical Update and Reports First Quarter 2025 Financial Results
RPTX
Published on 05/13/2025 at 16:09
Exploring strategic alternatives to advance clinical stage pipeline and maximize shareholder value $124.2 million in cash and cash equivalents and marketable securities provides runway as of March 31, 2025
Repare Therapeutics Inc. (“Repare” or the “Company”) (Nasdaq: RPTX), a clinical-stage precision oncology company, today reported financial results for the first quarter ended March 31, 2025.
“During the first quarter of 2025 we continued our efforts to create long-term value for our shareholders via partnering and by advancing our novel pipeline programs,” said Steve Forte, President, Chief Executive Officer and Chief Financial Officer of Repare. “We announced a strategic partnership with DCx Biotherapeutics to out-license our discovery platforms, and we are exploring a full range of strategic alternatives and partnerships across our portfolio. We are well-positioned from an operational and financial standpoint to drive our clinical pipeline to key inflection points and remain on track to report initial data for both the LIONS and POLAR trials in the second half of this year.”
First Quarter 2025 and Recent Portfolio Highlights:
First Quarter 2025 Financial Results
About Repare Therapeutics Inc.
Repare Therapeutics is a clinical-stage precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and development of novel therapeutics. Repare Therapeutics has developed highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The Company’s clinical-stage pipeline includes RP-3467, a Phase 1 Polθ ATPase inhibitor; RP-1664, a Phase 1 PLK4 inhibitor; and lunresertib, a PKMYT1 inhibitor. For more information, please visit www.reparerx.com and follow @Reparerx on X (formerly Twitter) and LinkedIn.
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 and securities laws in Canada. All statements in this press release other than statements of historical facts are “forward-looking statements. These statements may be identified by words such as “aims,” “anticipates,” “believes,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “may,” “plans,” “possible,” “potential,” “seeks,” “will” and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding: the Company's out-license of its discovery platforms to DCx, including the potential benefits of the transaction and the receipt of out-licensing, clinical and commercial milestone payments and royalties under the out-license agreement; the Company’s plans for exploring strategic alternatives and partnerships across the clinical portfolio, including the Company's plans to seek a partner to fund further clinical development of lunresertib and other assets; the Company's anticipated cash runway; the design, objectives, initiation, timing, progress and results of current and future preclinical studies and clinical trials of the Company’s product candidates including the advancement of its three ongoing clinical trials. These forward-looking statements are based on the Company’s expectations and assumptions as of the date of this press release. Each of these forward-looking statements involves risks and uncertainties that could cause the Company’s clinical development programs, future results or performance to differ materially from those expressed or implied by the forward-looking statements. Many factors may cause differences between current expectations and actual results, including: the Company's ability to successfully pursue a strategic transaction on attractive terms, or at all; the potential that success in preclinical testing and earlier clinical trials does not ensure that later clinical trials will generate the same results or otherwise provide adequate data to demonstrate the efficacy and safety of a product candidate; the impacts of macroeconomic conditions, including tariffs and other trade policies, the conflict in Ukraine and the conflict in the Middle East, fluctuations in inflation and uncertain credit and financial markets, on the Company’s business, clinical trials and financial position; unexpected safety or efficacy data observed during preclinical studies or clinical trials; clinical trial site activation or enrollment rates that are lower than expected; the Company’s ability to realize the benefits of its collaboration and license agreements; changes in expected or existing competition; changes in the regulatory environment; the uncertainties and timing of the regulatory approval process; and unexpected litigation or other disputes. Other factors that may cause the Company’s actual results to differ from those expressed or implied in the forward-looking statements in this press release are identified in the section titled "Risk Factors" in the Company’s Annual Report on Form 10-K for the year ended December 31, 2024 filed with the Securities and Exchange Commission (“SEC”) and the Québec Autorité des Marchés Financiers ("AMF") on March 3, 2025., and in other filings made with the SEC and AMF from time to time, including the Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2025. The Company expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law. For more information, please visit reparerx.com and follow Repare on X (formerly Twitter) at @RepareRx and on LinkedIn at https://www.linkedin.com/company/repare-therapeutics/.
Repare Therapeutics Inc.
Consolidated Balance Sheets
(Unaudited)
(Amounts in thousands of U.S. dollars, except share data)
As of March 31,
As of December 31,
2025
2024
ASSETS
CURRENT ASSETS:
Cash and cash equivalents
$
84,455
$
84,717
Marketable securities
39,773
68,074
Income tax receivable
9,983
10,600
Other current receivables
1,586
1,746
Prepaid expenses
4,546
6,012
Total current assets
140,343
171,149
Property and equipment, net
1,108
2,294
Operating lease right-of-use assets
1,365
1,924
Income tax receivable
1,207
960
Other assets
—
179
TOTAL ASSETS
$
144,023
$
176,506
LIABILITIES AND SHAREHOLDERS’ EQUITY
CURRENT LIABILITIES:
Accounts payable
$
2,284
$
3,623
Accrued expenses and other current liabilities
15,270
19,819
Operating lease liability, current portion
1,372
1,845
Total current liabilities
18,926
25,287
Operating lease liability, net of current portion
—
88
TOTAL LIABILITIES
18,926
25,375
SHAREHOLDERS’ EQUITY
Preferred shares, no par value per share; unlimited shares authorized as of March 31, 2025 and December 31, 2024; 0 shares issued and outstanding as of March 31, 2025, and December 31, 2024
—
—
Common shares, no par value per share; unlimited shares authorized as of March 31, 2025 and December 31, 2024; 42,891,403 and 42,510,708 shares issued and outstanding as of March 31, 2025 and December 31, 2024, respectively
489,836
486,674
Warrants
27
10
Additional paid-in capital
83,066
82,191
Accumulated other comprehensive income
9
54
Accumulated deficit
(447,841
)
(417,798
)
Total shareholders’ equity
125,097
151,131
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY
$
144,023
$
176,506
Repare Therapeutics Inc.
Consolidated Statements of Operations and Comprehensive Loss
(Unaudited)
(Amounts in thousands of U.S. dollars, except share and per share data)
Three Months Ended March 31,
2025
2024
Revenue:
Collaboration agreements
$
—
$
52,404
Operating expenses:
Research and development, net of tax credits
20,270
32,970
General and administrative
7,652
8,618
Restructuring
3,265
—
Total operating expenses
31,187
41,588
(Loss) income from operations
(31,187
)
10,816
Other income (expense), net
Realized and unrealized (loss) gain on foreign exchange
(2
)
31
Interest income
1,538
2,968
Other expense, net
(22
)
(24
)
Total other income, net
1,514
2,975
(Loss) income before income taxes
(29,673
)
13,791
Income tax expense
(370
)
(629
)
Net (loss) income
$
(30,043
)
$
13,162
Other comprehensive loss:
Unrealized loss on available-for-sale marketable securities
$
(45
)
$
(141
)
Total other comprehensive loss
(45
)
(141
)
Comprehensive (loss) income
$
(30,088
)
$
13,021
Net (loss) income per share attributable to common shareholders:
Basic
$
(0.71
)
$
0.31
Diluted
$
(0.71
)
$
0.30
Weighted-average common shares outstanding:
Basic
42,591,730
42,234,001
Diluted
42,591,730
44,024,198
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