The Estee Lauder Companies Shares New Findings at the American Academy of Dermatology; Findings highlight pigmentation concerns and neurosensory processes in skin

Published: 2025-04-01 11:27:16 ET EL

NEW YORK- The Estee Lauder Companies Inc. (ELC) presented research at the 2025 American Academy of Dermatology (AAD) annual meeting, held in Orlando, Florida from March 7-11. The AAD annual meeting is the premier dermatology conference in the United States, facilitating education and collaboration among dermatologists and industry experts. The data presented by ELC scientists in ePosters represents the expertise within the Research & Development (R&D) teams.

'Estee Lauder Companies scientists were honored to be accepted to present their basic science and clinical findings at this year's meeting of the AAD,' said Tom Mammone, PhD, Vice President, Bioscience, Advanced Technology Pioneering, Bioscience and lead scientist for Clinique Laboratories. 'Our presence at the meeting allows us not only to introduce the dermatologist community to our work and demonstrate our commitment to research but also facilitates the next generation of skin care innovations by allowing us to learn from the best in the field.'

Additional poster details highlighting key data are as follows:

Title: Dual mechanisms of skin glycation on melanogenesis and prevention approaches

Presenter: Tom Mammone, PhD, Vice President, Advanced Technology Pioneering, Bioscience and lead scientist for Clinique Laboratories

Key Takeaways:

Advanced Glycation End-products (AGEs) have also been found to promote melanogenesis in skin, indicating that glycation might not only contribute to skin yellowness and dullness by directly forming yellow-brown chromophores, but also by stimulating the overproduction of melanin.

To assess the stimulation of melanin production by AGEs and the prevention efficacy of actives, normal human primary epidermal melanocytes were treated with AGE-BSA without actives, while 3D human pigmented epidermal model (MelaKutis) were treated with AGE-BSA without topical application of actives.

Dr. Mammone showed that AGE-BSA could directly stimulate melanin production both in melanocytes and in pigmented epidermal skin models. Also, he and his team have found that glycated-collagen could stimulate a novel inflammatory factor and known melanogenesis stimulator in HDFs, indicating that AGEs might also indirectly stimulate melanogenesis through dermal-epidermal crosstalk.

Several actives were found to be preventative of the glycation-melanogenesis cycle.

Title: A Facial Night Cream Containing Macrocystis pyrifera Ferment and Marine Complex for Enhancing Skin Appearance Following Cosmetic Dermatologic Treatments

Presenter: Lisa DiNatale, Director, Clinical Testing, La Mer Max Huber Research Laboratories

Key Takeaways:

A newly developed facial night cream, formulated with Macrocystis pyrifera ferment (MPF) and a Marine Complex (MC), accelerates skin recovery after non-surgical dermatologic treatments.

A 4-week clinical study post-glycolic acid peels and IPL treatments demonstrated significant improvements in skin radiance, texture, evenness, and reduction of crow's feet wrinkles, with no reported tolerance concerns.

These findings mark a significant advancement in post-procedure night skin care, providing dermatologists and patients with a clinically tested solution to optimize treatment recovery and results.

Clinique also hosted a booth in the AAD Exhibition Hall and presented the brand's newest innovations, focused on the latest in serum technologies to address top dermatological concerns including hyperpigmentation, de-aging, and hydration. Dr. Mammone led 4 in-depth sessions focused on the science behind the products. In addition, Clinique Educators also provided personalized consultations and product demonstrations, highlighting Clinique's expertise and commitment to learning from the dermatology community.

Around the world, ELC is dedicated to cutting-edge science with multidisciplinary expertise ranging from basic science and advanced technologies to the intersections of physics, chemistry, biology, and engineering. ELC R&D has 75 years of formulation authority and is deeply integrated into the scientific community, regularly presenting at leading events and publishing in peer-reviewed journals. ELC's R&D team consistently aims to develop the next generation of transformative, science-driven prestige beauty products, packaging, and experiences that deliver exceptional quality and performance for our consumers around the world.

About The Estee Lauder Companies Inc.

The Estee Lauder Companies Inc. (ELC) is one of the world's leading manufacturers, marketers, and sellers of quality skin care, makeup, fragrance, and hair care products, and is a steward of luxury and prestige brands globally. The company's products are sold in approximately 150 countries and territories under brand names including: Estee Lauder, Aramis, Clinique, Lab Series, Origins, M*A*C, La Mer, Bobbi Brown Cosmetics, Aveda, Jo Malone London, Bumble and bumble, Darphin Paris, TOM FORD, Smashbox, AERIN Beauty, Le Labo, Editions de Parfums Frederic Malle, GLAMGLOW, KILIAN PARIS, Too Faced, Dr.Jart+, the DECIEM family of brands, including The Ordinary and NIOD, and BALMAIN Beauty.