Vertex Pharmaceuticals Incorporated : 2025 Data Summary

VRTX

Published on 04/16/2026 at 12:00 pm EDT

We monitor and report metrics in areas that align with our corporate responsibility priorities. The table below discloses our three-year progress on select indicators.

METRIC

2025

2024

2023

BUSINESS AND ETHICS

R&D Investment (GAAP, in USD thousands)

4,042,500

8,258,7001

3,690,000

R&D Investment as a Percentage of Business Operating Expenses (GAAP)

70%

85%

77%

% of Employees Who Completed Their Annual Code of Conduct Training

100%

100%

100%

% Spend on Small Businesses2

13.8%

17.3%

18.1%

WORKPLACE

Total Employees Globally (approximate)

6,400

6,100

5,100

New Hires Globally (approximate)

900

1,100

1,100

Voluntary Turnover Rate (Global, Trailing 12 Months Metric)

5.6%

4.4%

4.7%

COMMUNITY

Nonprofits Supported Through Matching Gift Program

2,775

2,592

2,183

Hours Volunteered by Employees During Work Time

13,974

12,715

10,013

% of Employees Who Volunteered on Global Week of Service

83%

70%

60%

ENVIRONMENT, HEALTH, SAFETY AND SUSTAINABILITY

TRIR (per 200,000 hours worked)3

0.13

0.18

0.33

DART (per 200,000 hours worked)3

0.12

0.16

0.15

% Square Feet of Buildings Operated That Are Green Certified

80%

79%4

82%4

2024 R&D Investment included a one-time acquired in-process research and development expense of $4.4 billion resulting from our acquisition of Alpine Immune Sciences, Inc.

For the 2025 U.S. gov. fiscal year (Oct. 1, 2024-Sep. 30, 2025).

ERM CVS provided limited assurance of safety rates (TRIR, DART) for 2020-2025. Assurance information for 2020-2024 can be found in the associated corporate responsibility (CR) reports. The 2025 ERM CVS Assurance Report and Basis of Reporting can be viewed at https://www.vrtx.com/responsibility/policies-positions-and-reports.

Percentage decreased due to an increase in our global footprint.

Vertex 2025 Data Summary | 1

METRIC

2025

2024

2023

Total GHG Emissions Scope 1 & Scope 2 Market-Based (metric tons CO2e)5,6

13,574

12,906

13,198

GHG Scope 1 (metric tons CO2e)5

12,296

8,976

8,311

GHG Scope 2 (metric tons CO2e)5,6

1,278

3,930

4,888

GHG Scope 3 (metric tons CO2e)

579,649

551,647

474,129

CDP Climate Change Survey Score

B

B

A-

% Energy From Renewable Sources

52%

50%

49%

Total Waste (metric tons)7

2,109

1,982

1,689

Nonhazardous Waste (metric tons)5,7

1,444

1,467

1,212

Nonhazardous Waste Diverted From Landfill (metric tons)5,7

588.8

596.7

403.1

% Nonhazardous Waste Recycled or Composted5,7

41%

41%

33%

Hazardous Waste (metric tons)5,7

664.5

514.7

476.9

Laboratory and Manufacturing Waste Recycled (metric tons)5

174.3

130.0

119.6

% Total Waste Diverted From Landfill5,7,8

59%

57%

52%

Total Water Withdrawn (megaliters)

188.4

137.8

169.3

2022 and 2023 GHG Scope 1 emissions were updated in April 2025 to include emissions at our Vertex Manufacturing Center that were previously attributed to a tenant. ERM CVS provided limited assurance of total GHG Emissions Scope 1 & Scope 2 Location- and Market-Based (metric tons CO2e), and waste data for 2020-2025. ERM CVS provided limited assurance of total GHG Emissions Scope 1 & Scope 2 Location- and Market-Based (metric tons CO2e), and waste data for 2020-2025. ERM CVS also provided reasonable assurance of Fan Pier Scope 1 (4,939 MT C02e), Scope 2 Location-Based (7,131 MT CO2e), and Scope 2 Market-Based (70.7 MTCO2e); UK IHQ Scope 1 (1.29 MT C02e), Scope 2 Location-Based (131 MT CO2e), and Scope 2 Market-Based (0 MTCO2e) for 2025. Assurance information for 2020-2024 can be found in the associated corporate responsibility (CR) reports. The 2025 ERM CVS Assurance Report and Basis of Reporting can be viewed at https://www.vrtx.com/sites/default/files/Environmental-Assurance-Statements.pdf.

Location-based Scope 2 emissions were 15,443 MT CO2e. For Scope 2 market-based emissions, international locations apply location-based IEA factors when residual emission factors set are not available.

8 Includes hazardous and nonhazardous waste diverted from landfill via recycling, composting, fuel blending and incineration for repurposing or energy recovery.

Waste figures represent waste associated with Vertex operations. This includes small-scale internal renovations but excludes expansions and new building construction.

Vertex 2025 Data Summary | 2

Vertex 2025 Data Summary |

Disclaimer

Vertex Pharmaceuticals Incorporated published this content on April 16, 2026, and is solely responsible for the information contained herein. Distributed via Public Technologies (PUBT), unedited and unaltered, on April 16, 2026 at 15:59 UTC.