Centene : 2025 Proxy Statement & 2024 Annual Report

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Our Mission

Transforming the health of the communities we serve, one person at a time.

Since its founding as a single local healthcare plan in 1984, Centene's heart and soul has been linked to supporting the health of the communities we proudly serve. We are committed to providing access to quality, culturally sensitive care for our members and communities.

Now, forty years later, this long-held commitment to supporting the health and health care of our members is encapsulated in our mission: Transforming the health of the communities we serve, one person at a time.

Our Values

Accountability - Courage - Curiosity - Trust - Service

These values support our efforts to realize our mission.

Our Culture

Letter from Our CEO and Our Chairman

Letter to Stockholders

From Our Chief Executive Officer and Our Chairman of the Board

March 27, 2025

Dear Stockholders:

In these early months of 2025, healthcare policy headlines are dominating the news and creating market uncertainty for investors. From where we stand, this volatility - while temporary - only reinforces the importance of Centene's focused and intense work over the last three years to improve our operational agility and strengthen our infrastructure, fostering resilience and readiness as an organization and as an essential member of the healthcare community.

Looking back, 2024 was a capstone year in our value creation journey, and rife with industry turbulence of its own. And yet, surrounded by landscape challenges, we delivered significant operational milestones and outperformed our top and bottom-line financial commitments in 2024 positioning our business well for the future.

A couple of key highlights:

• Thanks to an ongoing emphasis on and commitment to quality performance and operational excellence, we delivered substantial improvements in our Medicare STAR ratings, effectively positioning our Medicare business on a path to breakeven in 2027.

• We delivered another year of solid, profitable growth in our Individual business. Capitalizing on our leading market position, we pioneered program integrity changes that proactively reduced fraud, waste and abuse. In early 2024, our team introduced the "Agent of Record Lock" policy, setting the tone for the Centers for Medicare and Medicaid Services (CMS) to make this and other program integrity measures a market mandate heading into the Open Enrollment period.

• In our Medicaid business, we navigated a historic level of eligibility redetermination, partnering closely across 30 states to navigate membership and acuity shifts impacting millions of lives, while at the same time delivering an impressive string of RFP wins thereby securing the majority of our Medicaid business through the end of the decade.

• And, finally, we continued our work to build an industry-leading culture, operating as "One CenTeam" by focusing on service - to our partners, to our members, and to each other.

In 2024, we proved that our business has the fortitude to not only survive challenges, but thrive, continuing to evolve to better serve our customers and stakeholders.

We enter 2025 structurally stronger, more talented, more agile, and better positioned to execute against a pipeline of exciting growth opportunities.

Operationally, in 2025 we expect to collaborate with our state partners to more closely align Medicaid rates with the post-redeterminations book of business. Our Medicare Advantage business, following successful execution during the Annual Enrollment Period, will focus on key clinical and operational initiatives to advance our progress to break even in 2027. And, as the category leader, our Marketplace team will once again offer access to high quality and affordable healthcare - this year to approximately 5 million Americans - while expanding our movement into the emerging Individual Coverage Health Reimbursement Arrangement (ICHRA) market.

We are already in-motion on initiatives that leverage AI to drive quality and efficiency in our business and these will accelerate in 2025. For example, we are deploying AI within our provider contracting operations to reduce the manual labor associated with configuring and maintaining contracts, while enabling further automation and speed in processing payments to providers.

Letter from Our CEO and Our Chairman

AI is also helping us strengthen our analytics - an important lever for advancing initiatives such as Value Based Care across our businesses. Value-based payment models align the success of our providers with the well-being of our members. With more than 40% of our medical membership associated with value-based arrangements, we are better able to coordinate and support critical healthcare services - both big and small - for the lives we serve.

As an organization we subscribe to a philosophy that we can always do something more - more for our members, more for our state and federal partners and more for our shareholders. As we look ahead to 2025, new initiatives are scheduled to launch that aim to personalize and better facilitate care for our members. Our Illinois health plan is offering members with uncontrolled high blood pressure a 12-week comprehensive "Food Is Medicine" program. The program includes nutrition counseling along with an intentional combination of medically tailored meals, healthy food boxes and fresh produce vouchers. By creating sustainable changes in eating habits, our members can better support the treatment of their chronic disease - both inside and outside of the doctor's office.

In 2025, our recently announced partnership with the National Association of Community Health Centers (NACHC) will support value-based payment model adoption and improve maternal and child health outcomes. Community Health Centers uniquely serve our populations and share our strategy of delivering deeply local, integrated care. By working closely together, our goal is to drive differentiated health outcomes and transform the health of our shared communities at national scale.

Managed care organizations play a vital and often misunderstood role in the United States healthcare ecosystem. As stewards of taxpayer dollars, our charge is to lower healthcare costs while ensuring high-quality access to care. To do this, we focus on prevention, early intervention, and efficient care coordination. Investing in home health for our members can reduce the need for expensive (and often unnecessary) hospitalization. Connecting our members to resources that promote and protect health minimizes the need for more health care - things like access to healthy foods, transportation, and childcare. Over more than 40 years, Centene has worked to improve health care for low income and working Americans. But we believe there is more we can do to transform the communities we serve by focusing on a more holistic, comprehensive, and outcomes-oriented approach to health, instead of just health care. We intend to leverage our platform that today serves 28 million Americans to advocate on their behalf for system-wide changes that bring more seamless experiences and improved outcomes to those with the fewest resources and the most complex needs.

We look forward to delivering on our mission for our customers and our shareholders, as well as advancing the agenda nationally to make healthcare work better in 2025 and beyond.

Sincerely,

Sarah M. London

Chief Executive Officer

Frederick H. Eppinger

Chairman of the Board of Directors

Notice of 2025 Annual Meeting of Stockholders

Notice of 2025 Annual Meeting of Stockholders

Time and Date

10:00 AM, Central Time, on Tuesday, May 13, 2025

Place

Centene Plaza

Record Date

7700 Forsyth Boulevard St. Louis, Missouri 63105 Centene Auditorium

Stockholders as of March 14, 2025 are entitled to vote

Voting Items Proposal

Board Vote Recommendation For Further Details

(1) To elect eleven directors to hold office until the 2026 Annual Meeting of Stockholders or until their successors are duly elected and qualified;

FOR each Page 26

director nominee

(2) To cast a non-binding advisory vote on the compensation of the Company's Named Executive Officers;

FOR

Page 69

(3) To ratify the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025;

(4) To approve the Company's 2025 Stock Incentive Plan; and

FORFOR

Page 114

Page 120

(5) and (6) Stockholder proposals

AGAINST

Page 130

Stockholders will also transact such other business as may properly come before the Annual Meeting or at any convening or reconvening of the Annual Meeting following a postponement or adjournment of the Annual Meeting.

Stockholders or their legal proxy holders who wish to attend the Annual Meeting must preregister. Requests for preregistration must be received by us no later than 11:59 AM Eastern Time on May 9, 2025. For complete instructions for preregistering, see page 138 of this proxy statement.

On or about March 27, 2025, we mailed to our stockholders either 1) a copy of our proxy statement, a proxy card and 2024 Annual Report on Form 10-K or 2) a Notice of Internet Availability of Proxy Materials (Availability Notice), which indicates how to access the proxy materials on the internet. We believe furnishing proxy materials to our stockholders on the internet provides our stockholders with the information they need while lowering the costs of delivery and reducing the environmental impact of the distribution process.

By order of the Board of Directors,

Christopher A. Koster

Secretary and General Counsel

St. Louis, Missouri March 27, 2025

Important Notice Regarding the Availability of Proxy Materials for the 2025 Annual Meeting of Stockholders to be held on

May 13, 2025: The accompanying proxy statement and the 2024 Annual Report on Form 10-K are available atwww.ProxyVote.com.

Table of Contents

Table of Contents

Letter from Our CEO and Our Chairman3

Notice of2025Annual Meeting of Stockholders5

Who We Are7

Company Overview8

2024Financial and Business Highlights9

Execution of Strategy9

Our Competitive Strengths 11

Corporate Sustainability 11

Proxy Summary 16

Board Information 16

2024 Stockholder Engagement and Response 19

Governance Highlights 20

Executive Compensation Overview 21

Compensation Best Practices 24

Board and Governance Matters 26

Proposal 1 - Election of Directors 26

Board Overview 27

2025 Director Nominees 31

Independence of Directors 43

Director Nomination Process 44

Stockholder Recommendations of Director Candidates 44

Corporate Governance 45

Corporate Governance Guidelines 45

Proxy Access 46

Board and Committee Structure 47

Director Engagement 53

Board Oversight of Risk Management 55

Oversight of Corporate Sustainability 60

Stockholder Engagement 61

Other Governance Policies and Practices 64

Related Party Transactions 64

Compensation of Directors 65

Executive Officers 68

Proposal 2 - Advisory Resolution to Approve

Executive Compensation 69

Executive Compensation 70

Compensation Discussion and Analysis 70

Compensation and Talent Committee Report 98

Executive Compensation Tables 99

Pay Versus Performance 110

CEO to Median Employee Pay Ratio Information 113

Proposal 3 - Ratification of Appointment of

Independent Registered Public Accounting Firm 114

Proposal 4 - Approval of the 2025 Stock

Incentive Plan 120

Proposal 5 - Stockholder Proposal 130

Proposal 6 - Stockholder Proposal 133

Security Ownership of Certain Beneficial Owners

and Management 135

Five Percent Beneficial Owners of Common Stock 135

Delinquent Section 16(a) Reports 136

Equity Compensation Plan Information 137

Commonly Asked Questions and Answers About the

Annual Meeting 138

Other Matters 143

Committee Reports 143

Proxy Solicitation Costs 143

Stockholder Proposals and Director Nominations 143

Multiple Stockholders Having the Same Address 144

Requests for Additional Information 144

Forward-Looking Statements 145

Appendix A - Reconciliation of Non-GAAP Measures 146

Appendix B - 2025 Stock Incentive Plan 149

Who We Are

Today, Centene is the largest Medicaid managed care organization, the largest carrier on the Health Insurance Marketplace and the largest stand-alone Medicare Prescription Drug Plan (PDP) provider in the country, while also having an established Medicare presence. In addition, Centene has increased its market density to serve other low-income and medically complex populations and is uniquely positioned to serve individuals who are dually eligible for both Medicaid and Medicare.

#1 carrier in the nation

2025 Footprint

on the Health Insurance Marketplace

$35.5 billion

$145.5 billion

in cash and investments*

premium and service

revenues in 2024

60,500

28.6 million

employees*

members*

#46

#22

in 2024 Fortune Global 500

in 2024 Fortune 500

* As of December 31, 2024

More than 1 in 15 individuals across all 50 states

Centene offers affordable and high-quality products to more than 1 in 15 individuals across the nation, including Medicaid and Medicare members (including Medicare PDP) as well as individuals and families served by the Health Insurance Marketplace.

Addressing member needs through innovation

Advanced Technology Systems and Tools

Incentives for Healthier Living

Personal Member Outreach and Support

Helping Mothers and their Babies

Company Overview

Centene is a leading healthcare enterprise that is committed to helping people live healthier lives. The Company takes a local approach - with local brands and local teams - to provide fully integrated, high-quality and cost-effective services to government-sponsored and commercial healthcare programs, focusing on under-insured and uninsured individuals. Centene offers affordable and high-quality products to more than 1 in 15 individuals across the nation, including Medicaid and Medicare members (including Medicare PDP) as well as individuals and families served by the Health Insurance Marketplace. Our mission is to transform the health of the communities we serve, one person at a time.

Centene provides access to high-quality healthcare, innovative programs and a wide range of health solutions that help families and individuals get well, stay well and be well. Centene treats the whole person, an approach that is delivered locally and backed by the scale of Centene's expertise, data and resources. Through this approach and our commitment to sustainable partnerships, we work with local community organizations to realize our mission.

Centene's Path Forward

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Focus on Medicaid, Marketplace and Medicare, capitalizing on the significant expansion opportunities in each market

Build from the strength of our market positions, evolve with the market and create significant disruptive growth by leveraging our inherent and differentiated strengths to explore logical extensions to our core lines of business

Transform our business by leveraging industry-leading, mission-driven talent, and continuing to invest in our data analytics and capabilities

2024 Financial and Business Highlights

Our 2024 financial and business results reflect execution in our diverse portfolio across the Company's three major product lines.

2024 Financial Results

$163 billion

$6.31

$7.17

(10)%

Total Revenues, a 6% increase vs. 2023

Diluted Earnings Per Share (EPS) Adjusted Diluted EPS, an increase of 7% vs. 2023

Total Shareholder Return (TSR) 3-Year CAGR

Medicaid

Marketplace

Medicare

We are the largest Medicaid Managed Care Organization

We are the #1 carrier on the Health Insurance Marketplace

Within Medicare Advantage we have the largest concentration of Dual Eligible Special Needs Plans (D-SNP) members compared to our peers

13.0 million members across 30 states

4.4 million members across 29 states

1.1 million Medicare Advantage members across 37 states and 6.9 million PDP members in 50 states

Refer to Appendix A for reconciliations of non-GAAP measures included throughout this proxy statement.

Execution of Strategy

Our growth over the past decade has positioned us to be a leader in the healthcare industry and enabled the Company to stay focused on its mission while also delivering strong financial performance for its stockholders. Centene has a unique and powerful platform, and we are working to fortify its foundation to fuel our next phase of innovation and growth. We are focused on strong, long-term growth grounded in our core product lines, investing in becoming easy to work with by building modern systems and processes, and curating an enhanced network of partnerships designed to drive value across our portfolio.

We are focused on making strategic decisions and investments to create additional value in the short-term and to seek opportunities that position the organization for long-term strength, profitability, growth and innovation. In addition to creating stockholder value, we are modernizing and improving how we work in order to propel our organization to new levels of success and elevate the member and provider experiences. With trends in the personalization of healthcare technology, we continue the use of data and analytics to improve the provider and member experience. We continue to believe we have both the capacity and capability to successfully navigate industry changes to the benefit of our members, customers, providers and shareholders.

10

3 Years of Accomplishments

Over the last three years, we have delivered numerous accomplishments, including:

$27.5 billion growth Investment grade

rating by 2 of the 3 major rating agencies

• Momentum on Stars and quality

'24 vs. '21

Premium and Service Revenue1

• Investing & building in long-term growth areas and opportunities (HIDE/FIDE4, ICHRA)

12% CAGR

11 Divestitures

• Successful PBM transition

Adj. Diluted EPS2 growth Despite Medicare Stars decline & unprecedented Medicaid redeterminations headwinds

• USMM

• PANTHERx

• Ribera Salud

• Magellan Rx

• Ongoing SG&A efficiencies, incorporating simplification of operations

• HealthSmart

• Centurion

101 million

• Magellan Specialty

• Team and talent successes

shares repurchased3

• Apixio

• Circle Health

• Operose Health

• Collaborative Health Systems

1 Premium and Service Revenue growth based on $145.5 billion as of December 31, 2024 compared to $118.0 billion as of December 31, 2021.

2 For purposes of calculating the 3-Year CAGR, using adjusted diluted EPS $7.17 and $5.15 for December 31, 2024 and 2021, respectively. Refer to Appendix A for reconciliations of non-GAAP measures included throughout this proxy statement.

3 Shares repurchased from January 2022 through December 2024.

4 Highly Integrated Dual Eligible (HIDE) and Fully Integrated Dual Eligible (FIDE) plans.

Disclaimer

Centene Corporation published this content on March 27, 2025, and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on March 27, 2025 at 21:31:10.447.